Upon successful completion of this activity, participants should be able to describe: 1. The benefits and limitations of both conventional and advanced imaging in evaluating patients with multiple myeloma and related plasma cell dyscrasias. 2. Imaging findings of key significance for clinical management of patients with multiple myeloma and related plasma cell dyscrasias. 3. Common and sometimes life-threatening complications of myeloma and its treatment.Target Audience Journal SAMs are designed for all nuclear medicine specialists and other physicians, pharmacists and technologists who practice diagnostic and/or therapeutic nuclear medicine. Faculty Disclosure(s) Ronald C. Walker, MD, FACNM; Tracy L. Brown, MD, PhD; Laura B. Jones-Jackson, MD; Lorraine De Blanche, MD; Twyla D. Bartel, DO In accordance with ACCME Revised Standards for Commercial Support and SNMMI Conflict-of-Interest Policy, the authors have indicated no relevant relationships that could be perceived as a real or apparent conflict of interest. Disclosure of a relationship is not intended to suggest or to condone bias but is made to provide participants with information that might be of potential importance to their evaluation of the activity.