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JNMT (December 2012) A New Era of Clinical Dopamine Transporter Imaging Using 123I-FP-CIT
JNMT, Volume. 40, Number 4, December 2012

JNMT (December 2012) A New Era of Clinical Dopamine Transporter Imaging Using 123I-FP-CIT

JNMT, Volume. 40, Number 4, December 2012

Member Fee: Free
Non-Member Fee: $15.00

Release Date: December 1, 2012
Expiration Date: December 31, 2015

Author

Eunkyung Park

Department of Nuclear Medicine, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York

123I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (123I-FP-CIT) was approved for clinical use in 2011 by the Food and Drug Administration. 123I-FP-CIT is a radioligand for brain dopamine transporter (DAT) imaging that is useful for the differential diagnosis of Parkinson disease (PD) and other diseases that mimic PD. The sensitivity and specificity of 123I-FP-CIT SPECT for PD diagnosis are more than 90% and equivalent to those of other DAT SPECT methods. In the near future, the clinical indications of DAT imaging are expected to be broadened; for example, including treatment response assessment, disease progression monitoring, and early diagnosis of premotor PD in each individual patient.

Key Words: dopamine transporter; Parkinson disease; FP-CIT; ioflupane; DaTSCAN

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